Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 5, Pages 2984-2990Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02897
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21861019, 21562025]
Ask authors/readers for more resources
The cascade reactions between NH2-functionalized enaminones and sulfonyl hydrazines have been developed for the synthesis of fully substituted pyrazoles. By making use of the hydrophilic primary amino group in the enaminones, the reactions proceed well in the medium of pure water in the presence of molecular iodine, TBHP, and NaHCO3 via cascade C-H sulfonylation and pyrazole annulation. The cleavage of the C-N bond in enaminones is confirmed by the experiment using N-15-labeled enaminone.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available