Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 64, Issue -, Pages 206-217Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.10.020
Keywords
Gut microbiota; Adipose tissue; Energy metabolism; SCFAs; LPS; Probiotics
Funding
- Major National Scientific Research Projects [201503943102]
- National Nature Science Foundation of China [31572365]
- Key Sci-tech innovation team of Shaanxi province [2017KCT-24]
- Fundamental Research Funds for the Central Universities
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Normally, the gut microbiota has a mutually beneficial association with host health and maintains its commensal status in mammals. Conversely, it can also negatively influence host physiology under some certain circumstances, including obesity and other disease states. Although numerous gut microbial functions directly affect the gastrointestinal tract, in this paper, we focus on the influences of the gut microbiota on host adipose tissue and energy metabolism, particularly lipometabolism. We thoroughly discuss two important microbial products, short-chain fat acids and lipopolysaccharides, which are linked to several mechanisms involved in obesity and adipose, including differentiation, energy metabolism and immunity. Furthermore, this review also addresses some potentially beneficial functions of probiotics, which can serve to prevent or alleviate host pathological states, including dysbacteriosis, obesity, low-grade inflammation and metabolic syndrome. (C) 2018 Elsevier Inc. All rights reserved.
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