Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 64, Issue -, Pages 152-161Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.10.014
Keywords
Obesity; Diallyl disulfide; Phosphodiesterase 5; Green tea; Hyperlipidemia; Hyperinsulinemia
Funding
- JSPS KAKENHI [22228002, 15H02448]
- Grants-in-Aid for Scientific Research [15H02448] Funding Source: KAKEN
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Obesity is a major problem in developed countries and a burden on social health care systems. Several epidemiological studies showed the protective effects of green tea against obesity-related diseases. Cyclic guanosine monophosphate (cGMP) acts as a mediator for the physiological effects of (-)-epigallocatechin-3-O-gallate, the major constituent of green tea. Here, we showed that the level of phosphodiesterase 5, a negative regulator of cGMP, was up-regulated in adipose tissues of high-fat/high-sucrose (HF/HS) diet-fed mice and that this up-regulation was ameliorated by diallyl disulfide (DADS), the major organosulfur in garlic. A green tea extract (GT) and DADS in combination attenuated HF/HS diet-induced adipose increase and triglyceride accumulation in the liver. In these mechanisms, the combination regimen suppressed the HF/HS diet-induced up-regulation of fatty acid synthesis-related enzymes including sterol regulatory element-binding protein-1 (SREBP-1), fatty acid synthase, and stearoyl-CoA desaturase-1. Moreover, this combination diet up-regulated thermogenesis-related genes including peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1 alpha and uncoupling proteins in both white and brown adipose tissues. In conclusion, we identified DADS as an enhancer of the anti-obesity effect of GT accompanied by the suppression of SREBP-1 and activation of PPAR axis. The combination diet is a novel and easily applicable approach against obesity-related diseases. (C) 2018 Elsevier Inc. All rights reserved.
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