Journal
JOURNAL OF NUTRITION HEALTH & AGING
Volume 23, Issue 4, Pages 348-353Publisher
SPRINGER FRANCE
DOI: 10.1007/s12603-019-1172-3
Keywords
Rehabilitation; gait impairments; sarcopenia; nutrition; nutritional supplement
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ObjectiveTo investigate the effects of continuous intervention with branched chain amino acids-enriched nutritional supplements from the acute phase to convalescent rehabilitation wards in inpatients with gait impairments.DesignOpen-label, randomized, parallel-group comparison study (UMIN Clinical Trials Registry ID: UMIN000018640).SettingAcute care and convalescent rehabilitation wardsParticipantsWe studied 80 patients undergoing stand/gait training.InterventionsParticipants in the intervention group (RJ group) received nutritional supplements (jelly foods comprising 2500 mg BCAA and 20 IU vitamin D) twice a day until hospital discharge.MeasurementsThe primary outcome was the motor components of the Functional Independence Measure (FIM-m), and the secondary outcome was skeletal muscle mass index.ResultsAnalyses were conducted on 55 patients who were able to perform stand/gait training continuously from the acute until the recovery phases. FIM-m was significantly elevated in the RJ group and the control group, but no difference was noted between the two groups. Only the RJ group showed a significant increase in skeletal muscle mass index, and the amount of variation was significantly different between the two groups (the control group decreased an average of 2.2% and the RJ group increased an average of 4.3%; P = 0.014). A significant decrease in body weight was found only in the control group (P = 0.084).ConclusionsNutritional interventions using branched chain amino acids (BCAA)-enriched nutritional supplements demonstrated no significant difference in activities of daily living; however, an increase in skeletal muscle mass was noted. Skeletal muscle mass and body weight differed significantly between the two groups, and BCAA-enriched nutritional supplements intake in acute and convalescent rehabilitation wards may be effective for the prevention of malnutrition and sarcopenia.
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