Journal
JOURNAL OF NUTRITION
Volume 149, Issue 3, Pages 381-397Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jn/nxy304
Keywords
lycopene; carotenoids; genetics; prostate cancer; tomato
Categories
Funding
- National Cancer Institute of the National Institutes of Health [R01CA112632, P30CA016058]
- National Center for Advancing Translational Sciences [UL1TR001070]
- National Center for Complementary and Integrative Health
- Office of Dietary Supplements [K99/R00 AT008576]
- USDA Agricultural Research Service [CRIS 3092-51000-056-03S]
- Ohio State University's Food Innovation Center
- Center for Advancement of Functional Foods Research and Entrepreneurship
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Background: Human plasma and tissue lycopene concentrations are heterogeneous even when consuming controlled amounts of tomato or lycopene. Objectives: Our objective is to determine whether single nucleotide polymorphisms (SNPs) in or near known or putative carotenoid metabolism genes [beta-carotene 15,15' monooxygenase 1 (BCO1), scavenger receptor class B type 1 (SCARB1), ATP-binding cassette transporter subfamily A member 1 (ABCA1), microsomal triglyceride transfer protein (MTTP), apolipoprotein B-48, elongation of very long chain fatty acids protein 2 (ELOVL2), and ATP-binding cassette subfamily B member 1 (ABCB1), and an intergenic superoxide dismutase 2, mitochondrial-associated SNP] are predictive of plasma lycopene responses to steady state tomato juice consumption. Methods: Secondary linear regression analyses of data from a dose-escalation study of prostate cancer patients [n=47; mean +/- SEM age: 60 +/- 1 y; BMI (in kg/m(2)): 32 +/- 1] consuming 0, 1, or 2 cans of tomato-soy juice/d (163 mL/can; 20.6 mg lycopene 1.2 mg beta-carotene/can) for 24 +/- 0.7 d before prostatectomy were conducted to explore 11 SNP genotype effects on the change in plasma lycopene and plasma and prostate tissue concentrations of lycopene, beta-carotene, phytoene, and phytofluene. Results: Two BCO1 SNP genotypes were significant predictors of the change in plasma lycopene, with SNP effects differing in magnitude and direction, depending on the level of juice intake (rs12934922 x diet group P = 0.02; rs6564851 x diet group P=0.046). Further analyses suggested that plasma beta-carotene changes were predicted by BCO1 rs12934922 (P < 0.01), prostate lycopene by trending interaction and main effects of BCO1 SNPs (rs12934922 x diet group P = 0.09; rs12934922 P = 0.02; rs6564851 P = 0.053), and prostate beta-carotene by BCO1 SNP interaction and main effects (rs12934922 x diet group P = 0.01; rs12934922 P < 0.01; rs7501331 P = 0.02). Conclusions: In conclusion, SNPs in BCO1 and other genes may modulate human plasma and prostate tissue responses to dietary lycopene intake and warrant validation in larger, human controlled feeding intervention and cohort studies. Genetic variants related to carotenoid metabolism may partially explain heterogeneous human blood and tissue responses and may be critical covariates for population studies and clinical trials.
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