Journal
JOURNAL OF NEURORADIOLOGY
Volume 46, Issue 4, Pages 268-275Publisher
MASSON EDITEUR
DOI: 10.1016/j.neurad.2019.02.005
Keywords
Pediatric brain; Brain development; Quantitative MRI; Synthetic MRI; Automatic Brain tissue volumetry; Myelin measurement
Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [16K19852]
- JSPS [JP16H06280]
- Japan Radiological Society
- Bayer Yakuhin [KJ-08]
- Impulsing Paradigm Change through Disruptive Technologies (ImPACT) Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan)
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Quantitative magnetic resonance imaging (MRI) with multislice, multi-echo, and multi-delay acquisition enables simultaneous quantification of R-1 and R-2 relaxation rates, proton density, and the B-1 field in a single acquisition, and requires only about 6 minutes for full-head coverage. Using dedicated SyMRI software, radiologists can generate any contrast-weighted image by manipulating the acquisition parameters, including repetition time, echo time, and inversion time. Moreover, automatic brain tissue segmentation, volumetry, and myelin measurement can also be performed. Using the SyMRI approach, a shorter scan time, an objective examination, and personalized MR imaging parameters can be obtained in daily clinical pediatric imaging. Here we summarize and review the use of SyMRI in imaging of the pediatric brain, including the basic principles of MR quantification along with its features, clinical applications, and limitations. (C) 2019 Elsevier Masson SAS. All rights reserved.
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