Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 122, Issue 1, Pages 1-4Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00118.2019
Keywords
Alzheimer's disease; amyloid-beta; sleep; tau
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Funding
- Boston University School of Medicine MD/PhD Dean's Scholarship
- Cure Alzheimer's Fund
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Cognitive impairment in older adults is associated with sleep and circadian rhythm disturbances. Numerous studies have linked disrupted sleep and circadian rhythms with amyloid-beta (A beta), a key pathological hallmark in Alzheimer's disease (AD). While previous evidence suggests that A beta initiates AD pathogenesis, tau, another major hallmark of AD, seems to drive neurodegeneration. Recent studies imply that sleep-wake cycles affect brain tau more significantly than A beta levels, leading to accelerated AD progression and cognitive decline. The study of sleep disturbances in AD is shedding light on our understanding of the mechanism underlying sleep disturbances in AD and dementia.
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