Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 328, Issue -, Pages 60-67Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2018.12.005
Keywords
Exercise intensity; CD4(+) T cell subsets; Cytokines; Inflammation; Autoimmune diseases
Categories
Funding
- National Natural Science Foundation of China [81402677]
- Natural Science Foundation of Projects of Henan Province [182300410325]
- Science and Technology Development of Henan Province or Kaifeng [172102410036, 162102410082, 162300410116, 172102310151, 1806010]
Ask authors/readers for more resources
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS). Evidence about experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, has been shown to modulate disease parameters within exercise intervention. However, these initial studies weren't carried out intensity of exercise in mice. This study explored the impacts of different-intensity swimming training on EAE mice. Female mice were given access to swimming with predetermined weight (moderated-intensity (ME) group is 0% body weight; high-intensity (HE) group is 4% body weight) for 6 weeks, were immunized to induce EAE and then continued swimming until sacrificed. Compared to non-exercise mice, ME training didn't affect EAE clinical symptoms and neuropathology. However, HE swimming attenuated EAE clinical scores, reduced infiltrating cells and demyelination of spinal cords. Analysis of CD4(+) T cell subsets from CNS of EAE showed the reduction of Th1 and Th17 populations and an increase of Treg in HE, not ME mice. Accordingly, HE training lead to a decrease of IFN-gamma and IL-17 and an increase of IL-10 and TGF-beta. Of note, HE, not ME, swimming induced an increase of brain derived neurotrophic factor in the CNS of EAE. Moreover, HE training upregulated Treg and downregualted antigen-specific T cell proliferation and Th1 and Th17 populations from draining lymph node cells. These results suggest that HE swimming training might have benefits on attenuating the progression and pathological hallmarks of EAE, thus representing an important non-pharmacological intervention for improvement of chronic inflammation or T-cell mediated autoimmunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available