Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 328, Issue -, Pages 68-72Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2018.12.007
Keywords
VEGF; Temporal lobe epilepsy; Pharmacoresistance; Neocortex
Categories
Funding
- National Council of Science and Technology of Mexico (CONACYT) [177594, 261481]
Ask authors/readers for more resources
The vascular endothelial growth factor (VEGF) system has been shown to play a crucial role in several neuropathological processes. Temporal lobe epilepsy (TLE) is the most common focal epilepsy type in adult humans. We assessed the protein expression levels of VEGF-A, VEGF-B, and VEGF-C, their specific receptors VEGFR-2 and -3, their accessory receptors neuropilins 1 and 2, and PI3 and Akt kinases, in temporal neocortex from pharmacoresistant TLE (PR-TLE) patients and control subjects by western blotting. All proteins were found to be significantly overexpressed in samples of PR-TLE patients, indicating that the VEGF system contributes to PR-TLE pathogenesis and should be further studied.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available