Journal
JOURNAL OF NEPHROLOGY
Volume 32, Issue 5, Pages 733-740Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s40620-019-00589-z
Keywords
Microbiota; Homocysteine; Hydrogen sulfide; Sulfane sulfur; Lanthionine; Chronic kidney disease; Uremia; Uremic toxins; Dialysis
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Funding
- European Uremic Toxin (EUTox) Work Group
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The gut microbiota is considered to be a novel important factor to take into account in the pathogenesis of chronic kidney disease and uremia. Much attention has been paid to specific uremic retention solutes of microbial origin, such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide. However, other novel less well studied compounds, such as hydrogen sulfide and related sulfur metabolites (sulfane sulfur, lanthionine, etc.), should be included in a more comprehensive appraisal of this topic, in light of the potential therapeutic opportunities for the future.
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