Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1180, Issue -, Pages 462-471Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2018.11.107
Keywords
Bioactive organotin complexes; Amino acids; MCRs; SC-XRD; Tumor cell lines
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Funding
- DGAPA, UNAM [PAPIIT IN-216616]
- CONACYT [271117]
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A family of pentacoordinated diorganotin(IV) compounds was synthesized and characterized through the advantageous approach of a multicomponent methodology involving the reaction between 4-(diethylamino)salicylaldehyde, dibutyltin oxide and including a series of L-amino acid fragments (alanine, valine, leucine, isoleucine, phenylalanine, tyrosine and methionine), all carried out in one-step, in excellent yields. Structures were elucidated by FTIR, HRMS and solution NMR (H-1, C-13 and Sn-119). Diorganotin(IV) derivatives crystallized easily and five unreported molecular structures were solved and analyzed by SC-XRD experiments; depending on the orientation of the alkyl residues different isomorphic arrays were found. Finally, pentacoordinated diorganotin(IV) complexes were tested against tumoral cell lines, HCT-15 (colon adenocarcinoma), HeLa (cervical uterine adenocarcinoma), MCF-7 (breast adenocarcinoma) and PC-3 (human prostate cancer) in order to evaluate their in vitro cytotoxicity. (C) 2018 Elsevier B.V. All rights reserved.
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