Journal
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Volume 30, Issue 2, Pages -Publisher
SPRINGER
DOI: 10.1007/s10856-019-6218-x
Keywords
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Funding
- PAMI [ROTEIRO/0328/2013, 022158]
- Research Infrastructure of the National Roadmap of Research Infrastructures of Strategic Relevance
- FCT
- European Union through the Centro2020
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Biofabrication allows the formation of 3D scaffolds through a precise spatial control. This is of foremost importance when aiming to mimic heterogeneous and anisotropic architecture, such as that of the osteochondral tissue. Osteochondral defects are a supreme challenge for tissue engineering due to the compositional and structural complexity of stratified architecture and contrasting biomechanical properties of the cartilage-bone interface. This review highlights the advancements and retreats witnessed by using developed bioinks for tissue regeneration, taking osteochondral tissue as a challenging example. Methods, materials and requirements for bioprinting were discussed, highlighting the pre and post-processing factors that researchers should consider towards the development of a clinical treatment.
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