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Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity
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Flagellin enhances NK cell proliferation and, activation directly and through dendritic cell-NK cell interactions
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Infection of epithelial and dendritic cells by Chlamydia trachomatis results in IL-18 and IL-12 production, leading to interferon-7 production by human natural killer cells
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Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production
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Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing
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CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15
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Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
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Perforin is required for primary immunity to Histoplasma capsulatum
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Granulysin, a T cell product, kills bacteria by altering membrane permeability
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JOURNAL OF IMMUNOLOGY (2000)
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Acidic pH inhibits non-MHC-restricted killer cell functions
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NK cells eliminate Cryptococcus neoformans by potentiating the fungicidal activity of macrophages rather than by directly killing them upon stimulation with IL-12 and IL-18
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