4.7 Review

The Biology and Clinical Features of Cutaneous Polyomaviruses

Journal

JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 139, Issue 2, Pages 285-292

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2018.09.013

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Funding

  1. National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR072655]
  2. Burroughs Wellcome Fund Career Award for Medical Scientists [1010978]
  3. American Cancer Society Research Scholar Award [RSG-18-058-01]

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Human polyomaviruses are double-stand DNA viruses with a conserved genomic structure, yet they present with diverse tissue tropisms and disease presentations. Merkel cell polyomavirus, trichodysplasia spinulosa polyomavirus, human polyomavirus 6 and 7, and Malawi polyomavirus are shed from the skin, and Merkel cell polyomavirus, trichodysplasia spinulosa polyomavirus, human polyomavirus 6 and 7 have been linked to specific skin diseases. We present an update on the genomic and clinical features of these cutaneous polyomaviruses.

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