Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 196, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2019.03.020
Keywords
Oxidovanadium complex; Aroylhydrazones; Crystal structure; Insulin-like activity; Hypoglycaemic
Funding
- Natural Science Foundation of Shandong Province [ZR2016BL03]
- Shandong Provincial Key RD Plan [2018YYSP017, 2017YYSP033]
- SDUT & Zibo City Integration Development Project [9001-117173]
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Three new oxidovanadium(V) complexes were designed, synthesized and characterized by C, H, N elemental analysis, single crystal X-ray diffraction , UV/Vis and IR spectra. Complex 1: [(VOLX)-X-1] (H-2 L-1 = (E)-N'-(2-hydroxybenzylidene)-3-methbenzohydrazide, HX = ethylmaltol = 2-ethyl-3-hydroxy-4-pyrone), Complex 2: [VOL2 (CH3O)(CH 3OH)], (H2L2 = C16H16N2O4 = (E)-N'-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide, CH3OH = methanol), Complex 3: [(VOLX)-X-3] (H-2 L-3 = (E)-N'-(3-ethoxy-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide). The insulin-like activity of the three complexes was tested. Both normal and streptozotocin (STZ)-diabetic mice were administered intragastrically for two weeks. It was found that the complexes at doses of 10.0 and 5.0 mg V.kg(-1) can significantly decrease the blood glucose level in STZ-diabetic mice, and the blood glucose level in the treated normal mice was not altered. The lesions of kidney and liver caused by diabetes have varying degrees of improvement.
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