Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 366, Issue -, Pages 329-337Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhazmat.2018.12.004
Keywords
Biosorption; Metabonomics; Benzo(a)pyrene; Phospholipid; Metabolism pathway
Categories
Funding
- National Natural Science Foundation of China [21577049, 41501352]
- Science and Technology Project of Guangzhou City [201707010255]
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The relationship between benzo(a)pyrene biodegradation and certain target biomolecules has been investigated. To regulate the degradation process, the associated metabolism network must be clarified. To this end, benzo(a) pyrene degradation, carbon substrate metabolism and exometabolomic mechanism of Bacillus thuringiensis were analyzed. Benzo(a)pyrene was degraded through hydroxylation catalyzed by cytochrome P450 hydroxylase. After the treatment of 0.5 mg L-1 of benzo(a)pyrene by 0.2 g L-1 of cells for 9 d, biosorption and degradation efficiencies were measured at approximately 90% and 80%, respectively. During this process, phospholipid synthesis, glycogen, asparagine, arginine, itaconate and xylose metabolism were significantly downregulated, while glycolysis, pentose phosphate pathway, citrate cycle, amino sugar and nucleotide sugar metabolism were significantly upregulated. These findings offer insight into the biotransformation regulation of polycyclic aromatic hydrocarbons.
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