Journal
JOURNAL OF GASTROENTEROLOGY
Volume 54, Issue 7, Pages 660-666Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00535-019-01561-1
Keywords
Hepatitis C; Liver transplantation; Glecaprevir; Pibrentasvir
Categories
Funding
- Research Program on Hepatitis from Japan Agency for Medical Research and development, AMED [JP18fk0210023h0002]
Ask authors/readers for more resources
BackgroundEfficacy of 8-week regimen with direct-acting antivirals (DAA) for patients with hepatitis C after liver transplantation has not been clarified. This study aimed to clarify the efficacy and safety of glecaprevir and pibrentasvir therapy for 8 and 12weeks in Japanese patients with recurrent hepatitis C after liver transplantation.MethodsA cohort study of liver transplant recipients with recurrent hepatitis C treated with glecaprevir (300mg/day) and pibrentasvir (120mg/day) was performed at nine liver transplant centers in Japan.ResultsTwenty-five patients with hepatitis C after liver transplantation were treated with glecaprevir and pibrentasvir. Twenty-four patients completed the treatment protocol; treatment was discontinued in one patient who had nausea at 3days after the initiation of treatment. All the 24 patients who completed the 8- or 12-week treatment protocol achieved a sustained virological response 12weeks after completion of treatment (SVR12). The SVR12 rates in patients with HCV genotype 1 and 2 were 100% (21 of 21 patients) and 75% (3 of 4 patients), respectively. All patients with prior DAA therapy failure (n=6), jaundice (n=4), and liver cirrhosis (n=4) achieved SVR12. Seven of 8 patients (88%) with severe renal impairment achieved SVR12. Adverse events occurred in 6 of 25 patients (24%), including serious adverse events in 2 patients (8%). Treatment-related adverse events were nausea, pruritus, and mild renal dysfunction.ConclusionsEight- or 12-week regimen of glecaprevir and pibrentasvir is efficacious and safe in patients with recurrent HCV infection after liver transplantation, even in difficult-to-treat populations, including patients with severe renal impairment, prior DAA experience, liver cirrhosis, or jaundice after liver transplantation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available