Journal
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Volume 837, Issue -, Pages 137-142Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2019.02.020
Keywords
Electrochemical detection; DNAzyme; Hybridization chain reaction; Chiral molecules recognition; Signal amplification
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Funding
- National Natural Science Foundation of China [21675074, 21675075]
- Innovation Team Development Plan of the Ministry of Education Rolling Support [IRT_15R31]
- Taishan Scholar Project of Shandong Province
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An electrochemical method for carnitine enantiomers recognition is proposed employing Cu (II)-L-cysteine complexes and signal amplification strategies based on DNAzyme and DNA assistant hybridization chain reaction (HCR). The reported method combined Cu (II)-amino acids complexes with DNAzyme and proposed a smart and efficient electrochemical method to recognize chiral molecules through the difference between homochiral interaction and heterochiral interaction. Moreover, further employment of hairpin DNA assistant HCR greatly enhanced the detecting signal, realizing the selective recognition of carnitine enantiomers in low concentrations. This study creatively provides a general sensing method for sensitive chiral molecules recognition without large-scale precision instruments.
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