Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 537, Issue -, Pages 694-703Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2018.11.036
Keywords
Langmuir monolayer; Cytosine-based nucleolipid; Computer simulations; Complementary base pairing
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Funding
- Ministry of Economy and Competitiveness of Spain [CTQ2014-57515-C2, CTQ2017-83961-R]
- Ministry of Economy and Competitiveness [RyC-2014-14956]
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Monolayers of a cytosine-based nucleolipid (1,2-dipalmitoyl-sn-glycero-3-(cytidine diphosphate) (ammonium salt), CDP-DG) at basic subphase have been prepared at the air-water interface both in absence and presence of guanine. The formation of the complementary base pairing is demonstrated by combining surface experimental techniques, i.e., surface pressure (pi)-area (A), Brewster angle microscopy (BAM), infrared spectroscopy (PM-IRRAS) and computer simulations. A folding of the cytosine-based nucleolipid molecules forming monolayer at the air-water interface occurs during the guanine recognition as absorbate host and is kept during several compression-expansion processes under set experimental conditions. The specificity between nitrogenous bases has been also registered. Finally, mixed monolayers of CDP-DG and a phospholipid (1,2-dimyristoyl-sn-glycero-3-phosphate (sodium salt), DMPA) has been studied and a molecular segregation of the DMPA molecules has been inferred by the additivity rule. (C) 2018 Elsevier Inc. All rights reserved.
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