Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 129, Issue 5, Pages 1845-1862Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI121985
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Funding
- Cancer Research UK [A1731]
- Cancer Research UK Oxford Centre DPhil Prize Studentship [BBRTJW00]
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Because metastasis is associated with the majority of cancer-related deaths, its prevention is a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the activity of cyclooxygenase-1 (COX-1) and COX-2. Aspirin impairs the biosynthesis of all prostanoids through the irreversible inhibition of both COX isoforms. Long-term administration of aspirin leads to reduced distant metastases in murine models and clinical trials, but the COX isoform, downstream prostanoid, and cell compartment responsible for this effect are yet to be determined. Here, we have shown that aspirin dramatically reduced lung metastasis through inhibition of COX-1 while the cancer cells remained intravascular and that inhibition of platelet COX-1 alone was sufficient to impair metastasis. Thromboxane A(2) (TXA(2)) was the prostanoid product of COX-1 responsible for this antimetastatic effect. Inhibition of the COX-1/TXA(2) pathway in platelets decreased aggregation of platelets on tumor cells, endothelial activation, tumor cell adhesion to the endothelium, and recruitment of metastasis-promoting monocytes/macrophages, and diminished the formation of a premetastatic niche. Thus, platelet-derived TXA(2) orchestrates the generation of a favorable intravascular metastatic niche that promotes tumor cell seeding and identifies COX-1/TXA(2) signaling as a target for the prevention of metastasis.
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