Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 104, Issue 8, Pages 3181-3191Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2018-02608
Keywords
-
Categories
Funding
- Harvard Clinical and Translational Science Center, from the National Center for Advancing Translational Science [1UL1TR002541-01, 1UL1TR001102-01, 8UL1TR 000170-05]
- Fundacion Alfonso Martin Escudero
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [T32DK007028]
- Catalan Society of Endocrinology
Ask authors/readers for more resources
Context: Oxytocin (OT) and vasopressin share anatomical pathways of synthesis and secretion, and patients with central diabetes insipidus (CDI) presumably are at risk for OT deficiency. However, an OT-deficient state in hypopituitary patients has not been established. Objectives: We hypothesized that men with CDI compared to patients with similar anterior pituitary deficiencies (APD) but no CDI and healthy controls (HC) of similar age and body mass index, would have lower plasma OT levels, associated with increased psychopathology. Design: Cross-sectional. Setting: Clinical research center. Participants: Sixty-two men (20 CDI, 20 APD, 22 HC), age 18 to 60 years. Interventions: Frequent sampling of blood every 5 minutes for OT over 1 hour and validated questionnaires to assess psychopathology. Main Outcomes: Pooled plasma OT levels; depressive, anxiety, and alexithymia symptoms; and quality of life. Results: The mean 1-hour pool of fasting OT levels was lower in CDI compared with APD and HC (P = 0.02 and P = 0.009, respectively), with no differences between APD and HC (P = 0.78). Symptoms of depression, anxiety, and alexithymia were more pronounced in CDI than in HC (P = 0.001, P = 0.004, and P = 0.02, respectively). Although CDI and APD reported worse physical health compared with HC (P = 0.001 and P = 0.005) with no differences between APD and CDI, only CDI reported worse mental health compared with HC (P = 0.009). Conclusions: We have demonstrated low plasma OT levels and increased psychopathology in hypopituitary men with CDI, suggestive of a possible OT-deficient state. Larger studies of both sexes are required to confirm these findings and clinically characterize hypopituitary patients with OT deficiency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available