Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 95, Issue 4, Pages 746-753Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.16-0348
Keywords
-
Funding
- Division of Intramural Research (DIR)
- National Institute of Allergy and Infectious Diseases (NIAID)
- Conselho Nacional de Pesquisa (CNPq)
- Fundacao de Amparo a Pesquisa de Minas Gerais (Fapemig)
Ask authors/readers for more resources
There is much debate about the interaction between helminths and allergic disease. The Hygiene Hypothesis, a very popular concept among scientists and the lay public, states that infections, especially during childhood, can protect against allergic diseases. Indeed, helminth infections are known to induce regulatory responses in the host that can help the control of inflammation (including allergic inflammation). However, these infections also induce type-2-associated immune responses including helminth-specific IgE that can cross-react against environmental allergens and mediate IgE-driven effector responses. Thus, it is the delicate balance between the parasites' anti- and pro-allergenic effects that define the helminth/allergy interface.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available