Journal
JOURNAL OF CHEMICAL PHYSICS
Volume 150, Issue 9, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.5086152
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Funding
- SERB [SB/SI/PC-55/2013]
- DST-Inspire
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A prime example of a non-equilibrium or active environment is a biological cell. In order to understand in vivo functioning of biomolecules such as proteins and chromatins, a description beyond equilibrium is absolutely necessary. In this context, biomolecules have been modeled as Rouse chains in a Gaussian active bath. However, these non-equilibrium fluctuations in biological cells are non-Gaussian. This motivates us to take a Rouse chain subjected to a series of pulses of force with a finite duration, mimicking the run and tumble motion of a class of microorganisms. Thus by construction, this active force is non-Gaussian. Our analytical calculations show that the mean square displacement (MSD) of the center of mass grows faster and even shows superdiffusive behavior at higher activity. The MSD of a tagged monomer in an active bath also shows superdiffusion at an intermediate time unlike a monomer of a Rouse chain. In the case of a short chain length, reconfiguration is slower and the reconfiguration time of a chain with N monomers scales as N-sigma, with sigma approximate to 1.6 - 2. In addition, the chain swells. We compare this activity-induced swelling with that of a Rouse chain in a Gaussian active bath. In principle, our predictions can be verified by future single molecule experiments. Published under license by AIP Publishing.
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