Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 10, Pages 17113-17126Publisher
WILEY
DOI: 10.1002/jcp.28470
Keywords
biomarker; cholangiocarcinoma; lncRNA; mechanism; prognosis
Categories
Funding
- National Natural Science Foundation of China [81602088]
- China Postdoctoral Science Foundation [2017M621305]
- Heilongjiang Postdoctoral Science Foundation [LBH-Z16096]
- Health and Family Planning Commission Research Project of Heilongjiang Province [2016-049]
- Innovative Science Foundation of Harbin Medical University [2016LCZX09]
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Cholangiocarcinoma (CCA) is one of the most fatal cancers in humans, with a gradually increasing incidence worldwide. The efficient diagnostic and therapeutic measures for CCA to reduce mortality are urgently needed. Long noncoding RNAs (lncRNAs) may provide the potential diagnostic and therapeutic option for suppressing the CCA development. LncRNAs are a type of non-protein-coding RNAs, which are larger than 200 nucleotides in length. Increasing evidence reveals that lncRNAs exhibit critical roles in the carcinogenesis and development of CCA. Deregulation of lncRNAs impacts the proliferation, migration, invasion, and antiapoptosis of CCA cells by multiple sophisticated mechanisms. Consequently, lncRNAs likely represent promising biomarkers or intervention targets of CCA. In this review, we summarize current studies regarding the biological functions and regulatory mechanisms of diverse lncRNAs in CCA.
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