Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 23, Issue 4, Pages 2645-2655Publisher
WILEY
DOI: 10.1111/jcmm.14160
Keywords
epithelial-to-mesenchymal transition; highly up-regulated in liver cancer; long non-coding RNA; oral squamous cell carcinoma
Categories
Funding
- National Natural Science Foundation of China [81572654]
- Basic Research Program of Shenzhen Innovation Council of China [JCYJ20160428173933559, JCYJ20150403091443286, JCYJ20150403091443303, SZBC2017023]
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Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy that exhibits high incidence worldwide. In diverse human cancers, the long non-coding RNA (lncRNA) highly up-regulated in liver cancer (HULC) is aberrantly expressed, but how HULC affects OSCC development and progression has remained mostly unknown. We report that HULC was abnormally up-regulated in oral cancer tissues and OSCC cell lines, and that suppression of HULC expression in OSCC cells not only inhibited the proliferation, drug tolerance, migration and invasion of the cancer cells, but also increased their apoptosis rate. Notably, in a mouse xenograft model, HULC depletion reduced tumorigenicity and inhibited the epithelial-to-mesenchymal transition process. Collectively, our findings reveal a crucial role of the lncRNA HULC in regulating oral cancer carcinogenesis and tumour progression, and thus suggest that HULC could serve as a novel therapeutic target for OSCC.
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