Journal
JOURNAL OF CELL SCIENCE
Volume 132, Issue 6, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.226183
Keywords
Intracellular parasite; Leishmania amazonensis; Cell invasion; Lysosome; Plasma membrane repair
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG)
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Intracellular parasites of the genus Leishmania are the causative agents of leishmaniasis. The disease is transmitted by the bite of a sand fly vector, which inoculates the parasite into the skin of mammalian hosts, including humans. During chronic infection the parasite lives and replicates inside phagocytic cells, notably the macrophages. An interesting, but overlooked finding, is that other cell types and even non-phagocytic cells have been found to be infected by Leishmania spp. Nevertheless, the mechanisms by which Leishmania invades such cells had not been previously studied. Here, we show that L. amazonensis can induce their own entry into fibroblasts independently of actin cytoskeleton activity, and, thus, through a mechanism that is distinct from phagocytosis. Invasion involves subversion of host cell functions, such as Ca2+ signaling and recruitment and exocytosis of host cell lysosomes involved in plasma membrane repair. This article has an associated First Person interview with the first author of the paper.
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