Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 145, Issue 4, Pages 1001-1012Publisher
SPRINGER
DOI: 10.1007/s00432-019-02854-x
Keywords
Acute lymphoblastic leukemia; Children; Native Escherichia coli-derived asparaginase; Multicenter trial
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Funding
- charity organization 'Kontakty-Kontakte e.V.' (Project title 'Kinderleukamie'), Berlin, Germany
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PurposeFavorable outcomes were achieved for children with acute lymphoblastic leukemia (ALL) with the first Russian multicenter trial Moscow-Berlin (ALL-MB) 91. One major component of this regimen included a total of 18 doses of weekly intramuscular (IM) native Escherichia coli-derived asparaginase (E. coli-ASP) at 10000 U/m(2) during three consolidation courses. ASP was initially available from Latvia, but had to be purchased from abroad at substantial costs after the collapse of Soviet Union. Therefore, the subsequent trial ALL-MB 2002 aimed at limiting costs to a reasonable extent and also at reducing toxicity by lowering the dose for standard risk (SR-) patients to 5000 U/m(2) without jeopardizing efficacy.MethodsBetween April 2002 and November 2006, 774 SR patients were registered in 34 centers across Russia and Belarus, 688 of whom were randomized. In arm ASP-5000 (n=334), patients received 5000 U/m(2) and in arm ASP-10000 (n=354) 10 000 U/m(2) IM.ResultsProbabilities of disease-free survival, overall survival and cumulative incidence of relapse at 10years were comparable: 792%, 86 +/- 2% and 17.4 +/- 2.1% (ASP-5000) vs. 75 +/- 2% and 82 +/- 2%, and 17.9 +/- 2.0% (ASP-10000), while death in complete remission was significantly lower in arm ASP-5000 (2.7% vs. 6.5%; p=0.029).Conclusion p id=Par4 Our findings suggest that weekly 5000 U/m(2)E. coli-ASP IM during consolidation therapy are equally effective, more cost-efficient and less toxic than 10000 U/m(2) for SR patients with childhood ALL.
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