Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 96, Issue 2, Pages 335-337Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.16-0700
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Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [P50AI098505]
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From November to December 2012 in Selingue-Mali, blood samples from 88 febrile patients who tested negative by malaria Paracheck (R) rapid diagnostic tests (RDTs) were used to assess the presence of sub-RDT Plasmodium falciparum as well as Borrelia, Coxiella burnetii, and Babesia applying molecular tools. Plasmodium sp. was present among 57 (60.2%) of the 88 malaria RDT-negative patients, whereas the prevalence of Borrelia, C. burnetii, and Babesia were 3.4% (N = 3), 1.1% (N = 1), and 0.0%, respectively. The additional diagnostic use of polymerase chain reaction (PCR) identified a high proportion of Plasmodium sp.-positive samples and although this may be a concern for malaria control, the respective PCR-identified malaria infections were less likely responsible for the observed fevers given the low parasite density. Also, the low infection levels of Borrelia and C. burnetii and lack of Babesia among the febrile patients call for further studies to assess the causes of fever among malaria RDT-negative patients in Selingue.
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