Journal
JOURNAL OF BIOMECHANICS
Volume 88, Issue -, Pages 95-103Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2019.03.025
Keywords
Portal vein; Hepatic hemodynamics; Helical flow; Cirrhosis; 4D flow MRI
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Funding
- NIH [UL1TR000427, TL1TR000429]
- GE Healthcare
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Characterization of hepatic blood flow magnitude and distribution can lead to a better understanding of the pathophysiology of liver disease. However, the underlying patterns and dynamics of hepatic flow, such as the helical flow structure that often develops following the spleno-mesenteric confluence (SMC) of the hepatic portal vein, have not yet been comprehensively studied. In this study, we used magnetic resonance image (MRI)-based computational models to study the effects of the helical flow structure and SMC geometry on portal blood flow distribution. Additionally, we examined these flow dynamics with four-dimensional (4D) flow MRI in a group of 12 cirrhotic patients and healthy subjects. A validation model was also created to compare computational data to particle image velocimetry (PIV) data. We found significant correlations between flow structure development, vessel geometry, and blood flow distribution in both virtually modified models and in healthy and cirrhotic subjects. However, the direction of these correlations varied among vessel configuration types. Nonetheless, validation model results displayed good qualitative agreement with computational model data. (C) 2019 Elsevier Ltd. All rights reserved.
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