Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 294, Issue 5, Pages 1488-1489Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.H119.007392
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Novel imaging techniques with ever-increasing resolution are invaluable tools for the study of protein deposition, as they allow the self-assembly of proteins to be directly investigated in living cells. For the first time, the acceleration in A beta 42 aggregation induced by the Arctic mutation was monitored in cells, revealing a number of distinct morphologies that form sequentially. This approach will help discriminate the impacts of mutations on amyloid protein processing, A beta aggregation propensity, and other mechanistic outcomes.
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