Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 16, Issue 9, Pages 2545-2555Publisher
WILEY
DOI: 10.1111/ajt.13778
Keywords
clinical research; practice; organ procurement and allocation; liver transplantation; hepatology; kidney transplantation; nephrology; organ perfusion and preservation; clinical trial
Categories
Funding
- European Union's Seventh Framework programme for research, technological development, and demonstration [305934]
- National Institute for Health Research [CL-2012-13-005] Funding Source: researchfish
Ask authors/readers for more resources
The increased demand for organs has led to the increased usage of higher risk kidney and liver grafts. These grafts from donation after circulatory death or expanded criteria donors are more susceptible to preservation injury and have a higher risk of unfavorable outcomes. Dynamic, instead of static, preservation could allow for organ optimization, offering a platform for viability assessment, active organ repair and resuscitation. Ex situ machine perfusion and insitu regional perfusion in the donor are emerging as potential tools to preserve and resuscitate vulnerable grafts. Preclinical findings have ignited clinical organ preservation research that investigates dynamic preservation, its various modes (continuous, preimplantation) and temperatures (hypo-, sub, or normothermic). This review outlines the current status of dynamic preservation of kidney and liver grafts and describes ongoing research and emerging clinical trials. The authors summarize recent advances in the field of dynamic preservation of kidneys and livers, and detail ongoing and upcoming research that will advance the field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available