Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 21, Issue 10, Pages 947-953Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2018.1563076
Keywords
Cibotium barometz; phenolic acid; allose; hepatoprotection
Funding
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-3-011]
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Two rarely phenolic acid-substituted alloses (1, 2) and one new glucoside (3), as well as nine known compounds (4-12) were isolated from rhizomes of Cibotium barometz (L.) J. Sm. Structures of 1-3 were established by extensively spectroscopic analyses (NMR, MS, etc.) and acid hydrolysis. All compounds were evaluated for the hepatoprotective activities against APAP-induced HepG2 cell damage. Compounds 1, 4-7, 10 exhibited significant hepatoprotective activities, even more strongly than positive control, bicycol. In addition, compounds 1 and 9 could reduce PC12 cell death induced by serum deprivation.
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