Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 16, Issue 9, Pages 2684-2694Publisher
ELSEVIER SCIENCE INC
DOI: 10.1111/ajt.13779
Keywords
clinical research; practice; health services and outcomes research; liver transplantation; hepatology; cardiovascular disease; comorbidities; complication: medical; metabolic; Organ Procurement and Transplantation Network (OPTN); risk assessment; risk stratification
Categories
Funding
- National Institutes of Health [1 F32 HL116151-01]
- American Liver Foundation (New York, NY)
- Alpha Omega Alpha Postgraduate Award
- National Institutes of Health's National Center for Advancing Translational Sciences [KL2TR001424]
Ask authors/readers for more resources
Assessment of major adverse cardiovascular events (MACE) after liver transplantation (LT) has been limited by the lack of a multicenter study with detailed clinical information. An integrated database linking information from the University HealthSystem Consortium and the Organ Procurement and Transplant Network was analyzed using multivariate Poisson regression to assess factors associated with 30- and 90-day MACE after LT (February 2002 to December 2012). MACE was defined as myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), cardiac arrest, pulmonary embolism, and/or stroke. Of 32 810 recipients, MACE hospitalizations occurred in 8% and 11% of patients at 30 and 90 days, respectively. Recipients with MACE were older and more likely to have a history of nonalcoholic steatohepatitis (NASH), alcoholic cirrhosis, MI, HF, stroke, AF and pulmonary and chronic renal disease than those without MACE. In multivariable analysis, age >65 years (incidence rate ratio [IRR] 2.8, 95% confidence interval [95% CI] 1.8-4.4), alcoholic cirrhosis (IRR 1.6, 95% CI 1.2-2.2), NASH (IRR 1.6, 95% CI 1.1-2.4), pre-LT creatinine (IRR 1.1, 95% CI 1.04-1.2), baseline AF (IRR 6.9, 95% CI 5.0-9.6) and stroke (IRR 6.3, 95% CI 1.6-25.4) were independently associated with MACE. MACE was associated with lower 1-year survival after LT (79% vs. 88%, p < 0.0001). In a national database, MACE occurred in 11% of LT recipients and had a negative impact on survival. Pre-LT AF and stroke substantially increase the risk of MACE, highlighting potentially high-risk LT candidates. Using an integrated database that links information from the University HealthSystem Consortium and the OPTN, the authors assess factors associated with 30- and 90-day major adverse cardiac events after liver transplantation and discover that cardiac events occur in 11% of liver transplant recipients, and that a history of atrial fibrillation and stroke are significant predictors of these events.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available