Journal
JOURNAL OF APPLIED ELECTROCHEMISTRY
Volume 49, Issue 4, Pages 423-432Publisher
SPRINGER
DOI: 10.1007/s10800-019-01288-0
Keywords
Graphene quantum dots; Gold nanoparticles; Electrochemical sensor; Squarewave stripping voltammetry; Norepinephrine
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Funding
- FONDECYT Chile [1180804]
- Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [21150242]
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In this work, a glassy carbon electrode modified with graphene quantum dots and gold nanoparticles (GCE/GQDs/AuNPs) was developed for norepinephrine (NE) determination using squarewave stripping voltammetry. GQDs were synthesized by citric acid pyrolysis and characterized by UV-Vis and fluorescence spectroscopy. The chemically synthesized AuNPs were characterized by transmission electron microscopy and UV-Vis spectroscopy (Plasmon Band). GCE/GQDs surface was characterized by Raman spectroscopy and scanning electron microscopy. The conditions for the determination of NE with GCE/GQDs/AuNPs were optimized. The linear range was observed between 0.5 and 7.5 mu molL(-1), with a detection limit (LOD) of 0.15 mu molL(-1). The proposed methodology was validated with spiked samples for good precision and accuracy. GCE/GQDs/AuNPs were used in pharmaceutical preparations (NE ampoules) and in rat brain tissue with satisfactory results. [GRAPHICS] .
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