Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 74, Issue 5, Pages 1202-1206Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkz025
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Funding
- Swedish research council for the Environment, Agricultural Sciences and Spatial Planning [942-2015-750]
- Swedish research council Vetenskapsradet [2015-02492, 521-2013-8633]
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Objectives: To investigate the origin of CMY-1/MOX-family beta-lactamases. Methods: Publicly available genome assemblies were screened for CMY-1/MOX genes. The loci of CMY-1/MOX genes were compared with respect to synteny and nucleotide identity, and subjected to phylogenetic analysis. Results: The chromosomal ampC genes of several Aeromonas species were highly similar to known mobile CMY-1/MOX variants. Annotation and sequence comparison revealed nucleotide identities >98% and conserved syntenies between MOX-1-, MOX-2- and MOX-9-associated mobile sequences and the chromosomal Aeromonas sanarellii, Aeromonas caviae and Aeromonas media ampC loci. Furthermore, the phylogenetic analysis showed that MOX-1, MOX-2 and MOX-9 formed three distinct monophyletic groups with the chromosomal ampC genes of A. sanarellii, A. caviae and A. media, respectively. Conclusions: Our findings show that three CMY-1/MOX-family beta-lactamases were mobilized independently from three Aeromonas species and hence shine new light on the evolution and emergence of mobile antibiotic resistance genes.
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