Journal
JOURNAL OF ANTIBIOTICS
Volume 72, Issue 6, Pages 449-460Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41429-019-0165-0
Keywords
-
Funding
- National Institutes of Health, under NIH [R01GM090262]
- NSF CRIF program [CHE -9808183]
- NSF [0840444, OSTI 97-24412]
- NIH [RR11973]
- National Science Foundation for independent research development
Ask authors/readers for more resources
Steryl glycosides are prevalent in nature and have unique biological activities dictated by sterol structure, sugar composition, and the stereochemical attachment of the aglycone. A single configurational switch can have profound biological consequences meriting the systematic study of structure and function relationships. Steryl congeners of N-acetyl neuraminic acid (NANA) impact neurobiological processes and may also mediate host/microbe interactions. In order to study these processes, a platform for the synthesis of beta-steryl sialosides has been established. Promoter-free glycosidations using a novel alpha-linked sialyl iodide donor efficiently provide unique amphiphilic sialoglycoconjugates for examining bioactivities in various systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available