Journal
JOURNAL OF ANTIBIOTICS
Volume 72, Issue 5, Pages 311-315Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41429-019-0161-4
Keywords
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Funding
- National Natural Science Foundation of China [31820103003, 31700042, 41676165]
- Guangdong Province [GDME-2018C005, 2015A030308013]
- Chinese Academy of Sciences [QYZDJ-SSWDQC004]
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Heterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led to the isolation of a novel isoindolequinone albumycin (1) and a known isoquinolinequinone mansouramycin A (2). The structure of 1 was elucidated on the basis of detailed 1D and 2D NMR spectroscopic analysis. Mansouramycin A (2) is active against methicillin-resistant Staphylococcus aureus ATCC 43300, with a MIC of 8 mu g ml(-1), while albumycin (1) displayed negligible antibacterial activities. This study represents another example of activation of secondary metabolites that are non-relevant to the heterologously introduced biosynthetic gene cluster in a bacterial host.
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