Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 68, Issue 3, Pages 961-968Publisher
IOS PRESS
DOI: 10.3233/JAD-180897
Keywords
Aged; cardiorespiratory fitness; cognition; executive function; memory
Categories
Funding
- Academy of Finland
- La Carita Foundation
- Alzheimer Association
- Alzheimer's Research and Prevention Foundation
- Juho Vainio Foundation
- Finnish Brain Foundation
- Novo Nordisk Foundation
- Finnish Social Insurance Institution
- Ministry of Education and Culture
- Salama bint Hamdan Al Nahyan Foundation
- Axa Research Fund
- EVO funding for University Hospital of Kuopio
- EVO funding for University Hospital of Oulu
- EVO funding for University Hospital of Turku
- EVO funding for Seinajoki Central Hospital
- EVO funding for Oulu City Hospital
- Swedish Research Council
- Swedish Research Council for Health, Working Life and Welfare
- Jochnick Foundation
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Background: Previous studies have found positive associations between cardiorespiratory fitness (CRF) and cognitive performance in older people but data are inconsistent and have methodological limitations. Objective: Our aimwas to study the longitudinal associations of CRF with executive functions, processing speed and memory as well as with the overall cognitive function in older people at risk for cognitive impairment. Methods: Participants (n = 421), mean age 69.0, were a sub-sample of The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). To be eligible, individuals were required to be 60-77 years old with a CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Dementia Risk Score of at least 6 points and cognition at mean level or slightly lower than expected for age. CRF was assessed as peak oxygen uptake (VO2peak, L/min) measured directly in a symptom-limited maximal exercise test on cycle ergometer at baseline and at 24 months. Cognitive performance was assessed using an extensive neuropsychological test battery (NTB) at baseline and at 24 months. NTB data were standardized to Z scores, and analyzed with the linear mixed model. Results: Over two years, VO2peak was associated with NTB total score (beta = 0.12, p = 0.01), executive functions (beta = 0.16, p = 0.01), and processing speed (beta = 0.25, p < 0.001), but not with memory (beta = 0.11, p = 0.12). Conclusion: Over two years follow-up, CRF was associated with executive functions and processing speed, and was related also to the overall cognitive function.
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