Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 67, Issue 33, Pages 9178-9186Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b00705
Keywords
chicoric acid; C. elegans; lifespan; aak-2; skn-1
Funding
- Salmon Scholarship at the Department of Food Science, University of Massachusetts Amherst
- Senior Talent Cultivation Program of Jiangsu University [18JDG023]
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Chicoric acid is a dicaffeoyl ester with many bioactivities, including antioxidation, antidiabetes, and anti-inflammation. A previous study reported that chicoric acid extended the lifespan in Caenorhabditis elegans; however, the mechanism behind the effect of chicoric acid on the extended lifespan remains unknown. Consistent with the previous report, chicoric acid (25 and 50 mu M) extended the maximum lifespan compared to the control (17.5 +/- 3.3 and 15.6 +/- 5%, respectively; p < 0.001 for both). The declines of the pumping rate and locomotive activity, two indicators of aging,, were delayed by chicoric acid. Moreover, chicoric acid enhanced resistance to oxidative stress in C. elegans. It was further determined that the extended lifespan by chicoric acid was in part via aak-2 [a homologue of adenosine monophosphate (AMP)-activated protein kinase] and skn-1 (a homologue of nuclear factor erythroid 2-related factor 2). The current findings suggest that chicoric acid has the potential to be used as an anti-aging bioactive compound.
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