Journal
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Volume 23, Issue 2, Pages 90-98Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13651501.2018.1519079
Keywords
Parental age; paternal age; maternal age; bipolar disorder; unipolar depression
Categories
Funding
- Janos Bolyai Research Fellowship of the Hungarian Academy of Sciences [UNKP-18-4-SE-33]
- New National Excellence Program of the Ministry of Human Capacities
Ask authors/readers for more resources
Objective: Advanced parental age might constitute a risk factor for various disorders. We tested whether this concerns also mood disorder patients. Methods: The study included 314 subjects (42 bipolar-BD patients; 21 manics and 21 depressives, 68 unipolar-UD, and 204 normal controls-NC). Analysis of Covariance (ANCOVA) and the calculation of the Relative Risk (RR) and the Odds Ratio (OR) were used for the analysis. Results: Paternal age differed between NC and UD patients (29.42 +/- 6.07 vs. 32.12 +/- 5.54; p = .01) and manics (29.42 +/- 6.07 vs. 35.00 +/- 5.75; p = .001) and maternal age between NC and manics (25.46 +/- 4.52 vs. 31.43 +/- 4.75; p < .001) and manic and UD (31.43 +/- 4.75 vs. 26.75 +/- 6.03; p = .002). The RR and OR values suggested that advanced parental age constitutes a risk factor for the development of mood disorders. Conclusions: In a non-dose dependent and gender-independent, advanced parental age constitutes a risk factor for the development of BD with index episode of mania (probably manic predominant polarity); only advanced paternal age constitutes a risk factor for the development of UD and BD with index episode of depression (probably depressive predominant polarity). This is the first study suggesting differential effect of advanced parental age depending on predominant polarity of BD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available