Interpolymer complexes of carbopol® 971 and poly(2-ethyl-2-oxazoline): Physicochemical studies of complexation and formulations for oral drug delivery

Carbopol (R) 971 and poly(2-ethyl-2-oxazoline) form hydrogen-bonded interpolymer complexes in aqueous solutions and their complexation is strongly dependent on solution pH. This work investigated the complexation between these polymers in aqueous solutions. The compositions of interpolymer complexes as well as the critical pH values of complexation were determined. The structure of these complexes was studied in solutions using transmission electron microscopy and in solid state using elemental analysis, FTIR spectroscopy and differential scanning calorimetry. Solid compacts were prepared based on interpolymer complexes and physical blends of these polymers and their swelling behaviour was studied in aqueous solutions mimicking the fluids present in the gastrointestinal tract. These materials were used to prepare oral formulations of mesalazine and its release from solid matrices was studied in vitro. It was demonstrated that the complexation between Carbopol (R) 971 and poly (2-ethyl-2-oxazoline) has a profound effect on the drug release from matrix tablets.