Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 54, Issue 5, Pages 1511-1524Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2019.4751
Keywords
non-coding RNA; microRNA; long non-coding RNA; drug resistance; gastric cancer
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Funding
- grant of Jilin Provincial Health and Family Planning Commission Training Plan of Young and Technological Core Project [2016Q023]
- Jilin Provincial Science and Technology Development Planning Project [20180101169JC]
- Jilin Provincial Health and Family Planning Commission Project [2016C051-2]
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Gastric cancer (GC) is one of the most prevalent and malignant types of cancer worldwide. In China, it is the second most common type of cancer and the malignancy with the highest incidence and mortality rate. Chemotherapy for GC is not always effective due to the development of drug resistance. Drug resistance, which is frequently observed in GC, undermines the success rate of chemotherapy and the survival of patients with GC. The dysregulation of non-coding RNAs (ncRNAs), primarily microRNAs (miRNAs or miRs) and long non-coding RNAs (lncRNAs), is involved in the development of GC drug resistance via numerous mechanisms. These mechanisms contribute to the involvement of a large and complex network of ncRNAs in drug resistance. In this review, we focus on and summarize the latest research on the specific mechanisms of action of miRNAs and lncRNAs that modulate drug resistance in GC. In addition, we discuss future prospects and clinical applications of ncRNAs as potential targeted therapies against the chemoresistance of GC.
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