Effects of not monitoring gastric residual volume in intensive care patients: A meta-analysis

Background: Monitoring gastric residual volume has been a common practice in intensive care patients receiving enteral feeding worldwide. Recent studies though, have challenged the reliability and necessity of this routine monitoring process. Several studies even reported improvements in the delivery of enteral feeding without monitoring gastric residual volume, while incurring no additional adverse events. However, the benefit of monitoring gastric residual volume remains controversial in intensive care patients. Objective: The aim of this review is to identify the effects of not monitoring gastric residual volume in intensive care patients through a meta-analysis of the data pooled from published studies that meet our inclusion criteria. Design: A systematic review Data sources: An electronic search of Embase, Pubmed, and the Cochrane Library was completed up to April 2018. The data included basic population characteristics, related complications, mortality, duration of mechanical ventilation and intensive care unit length of stay. Review methods: Eligibility and methodological quality of the studies were assessed by two researchers independently according to the Joanna Briggs Institute guidelines. The Review Manager Software was used to calculate the pooled risk ratio (RR), weighted mean difference, and the corresponding 95% confidential interval (95% CI). Sensitivity analyses were done by excluding each study. Publication bias analyses were conducted to avoid the exaggerated effect of the overall estimates. Results: Five studies involving 998 patients were included in this meta-analysis. Compared with monitoring gastric residual volume, not monitoring gastric residual volume decreased the rate of feeding intolerance in critically ill patients (RR=0.61, 95%CI 0.51-0.72), and did not result in an increment in the rate of mortality (RR=0.97, 95%CI 0.73-1.29, P=0.84) or the rate of ventilator-associated pneumonia (RR=1.03, 95%CI 0.74-1.44, P=0.85). There were also no differences in the duration of mechanical ventilation (MD=0.09, 95%CI, -0.99 to 1.16, P=0.88) or intensive care unit length of stay (MD=-0.18, 95%CI,-1.52 to 1.17, P=0.79). Conclusion: Except for an increased risk of vomiting, the absence of monitoring gastric residual volume was not inferior to routine gastric residual volume monitoring in terms of feeding intolerance development, mortality, and ventilator-associated pneumonia in intensive care patients. There is encouraging evidence that not measuring gastric residual volume does not induce additional harm to the patients. More multicenter, randomized clinical trials are required to verify these findings. (C) 2019 Elsevier Ltd. All rights reserved.