Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms20040874
Keywords
brain; insulin resistance; oxidative stress; mitochondrial dysfunction
Funding
- Medical University of Bialystok, Poland [N/ST/ZB/18/012/1118, N/ST/ZB/18/009/1118]
- National Science Centre, Poland [2018/29/N/NZ4/02011]
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The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, -amyloid accumulation, as well as neuronal apoptosis in the IR conditions.
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