Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms20061376
Keywords
UV-B filter; endocrine disruptor compound; human umbilical artery; vascular smooth muscle cells; relaxation; L-Type VOCC; soluble guanylyl cyclase; organ bath; planar cell surface area
Funding
- multiannual program contract of patronage UBI-Santander Totta [BID/FCS/2018]
- FEDER funds through the POCI-COMPETE 2020-Operational Programme Competitiveness and Internationalisation in Axis I-Strengthening Research, Technological Development and Innovation [POCI-01-0145-FEDER007491]
- FCT-Foundation for Science and Technology [UID/Multi/00709/2013]
- national funds (OE), through FCT-Fundacao para a Ciencia e a Tecnologia, I.P. [4, 5, 6, 57/2016, 57/2017]
- CESAM [UID/AMB/50017/2019]
- FCT/MCTES
- Fundação para a Ciência e a Tecnologia [UID/Multi/00709/2013] Funding Source: FCT
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Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world's most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).
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