Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 124, Issue -, Pages 838-845Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.11.231
Keywords
Gold nanoparticles; Wound dressing; Scale-up production; Kappa-carrageenan; Locust bean Gum
Funding
- Fundacao de Amparo a Pesquisa do Estado de Santa Catarina (FAPESC) [803/2016]
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In this study, polysaccharide-based hydrogel wound dressings containing in situ synthesized gold nanoparticles (AuNPs) were prepared by using a simple, fast and green protocol. The prepared hydrogels were characterized with UV-vis and infrared spectroscopy (FT-IR), and dynamic light scattering (DLS). The rheological and swelling properties and the feasibility to scale-up the wound dressing production from the lamination of the prepared hydrogel on non-woven fabric were also investigated. UV-vis spectra confirmed the AuNPs synthesis and the DLS results exhibited an increase in the size of AuNPs with increasing the initial Au3+ concentration. The rheological analysis showed that the augmentation of the initial Au3+ concentration reduces the gel viscosity and gelling temperature. Besides, the FT-IR spectra revealed that the AuNPs hinder the intermolecular interactions between kappa-carrageenan (kappa CG) and locust bean gum (LBG). The feasibility of scale-up the wound dressing production from the prepared hydrogel was confirmed through the lamination tests. (C) 2018 Elsevier B.V. All rights reserved.
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