Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 125, Issue -, Pages 376-382Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.11.248
Keywords
Chaetomium globosum CGMCC 6882; Polysaccharide; Antibacterial activity
Funding
- Natural Science Foundation of Youth Support Plan of Henan University of Technology [2017QNJH10]
- High Level Research Fund for Qualified People of Henan University of Technology [2017B5011]
- Program for Innovative Research Team (in Science and Technology) in University of Henan Province [191RTSTHN008]
- Natural Science Foundation of Henan Province Education Department [19A180015]
- national first-class discipline program of Light Industry Technology and Engineering [LITE2018-17]
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In present work, a polysaccharide (GCP) was produced by Chaetomium globosum CGMCC 6882 and characterized. GCP was composed of arabinose, galactose, glucose, xylose, mannose and glucuronic acid in a molar ratio of 0.64: 2.58: 23.53: 0.90: 2.47: 0.27 with molecular weight of 8.093 x 10(4) Da and polydispersity (Mw/Mn) of 1.014. Antibacterial characteristics and mechanism of GCP against Escherichia coli and Staphlococcus aureus were investigated by analysis of inhibition zones, minimum inhibitory concentration (MIC), alkaline phosphatase and beta-galactosidase activities, electrical conductivity and bacterial morphology. Results showed that the MIC of GCP against E. coli and S. aureus were 1.75 mg/mL and 0.67 mg/mL, respectively. Moreover, GCP exerted antibacterial activities by disrupting the inner membrane and increasing the cell permeability, but had no influences on cell wall. This work indicated that GCP could be explored as a promising antibacterial agent in food and pharmaceutical industries. (C) 2018 Published by Elsevier B.V.
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