Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 123, Issue -, Pages 436-445Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.11.086
Keywords
Carboxymethyl konjac glucomannan; Chitosan; Complex coacervation; Degree of substitution; Colon-targeted delivery
Funding
- Key R&D Project (Medical Foods) of Shandong Province, China [2018YYSP013]
- Major Fundamental Research Project of Shandong Province, China [ZR2018ZC0945]
- National Science Foundation of China [31571890]
- Agricultural Science and Technology Innovation Plan of the Shandong Academy of Agricultural Sciences, China [CXGC2016B16]
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Carboxymethyl konjac glucomannan (CMKGM) shows potential in the construction of colon-targeted delivery systems through electrostatic interaction-based techniques. Its coacervation with chitosan (CHI) was investigated as a function of degree of substitution (DS). CMKGMs displayed the same optimum coacervation conditions of pH 6.5 and mass ratio 1:1 with CHI, but the coacervate yield was positively related to their DS. The coacervation was weakened by the presence of NaCI, but was not affected in temperatures 25-75 degrees C and total biopolymer concentrations 0.05-0.15% (w/v). Both electrostatic interaction and hydrogen bonding were involved in the coacervation and a higher DS contributed a denser network structure, a smaller particle size, and greater elasticity. The coacervates maintained their structures in simulated gastrointestinal fluids, but could be degraded by the beta-mannanase in simulated colonic fluid. Hence, CMKGMs could be used in colon-targeted and enzyme-triggered delivery systems and the delivery performance could be tailored by varying their DS. (C) 2018 Elsevier B.V. All rights reserved.
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