Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 67, Issue -, Pages 458-464Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2018.12.019
Keywords
NLRP3 inflammasome; Pyroptosis; Neuroinflammation; Parkinson's disease
Categories
Funding
- Beijing Natural Science Foundation [7161011]
- National Natural Science Foundation of China [81573640, 81773925, U1402221]
- Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education of China [P201701]
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Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological feature of which is the death of dopamine neurons in the substantia nigra region. At present, neuronal death caused by inflammatory cytokine-mediated neuroinflammation is being extensively studied. The nucleotide-binding oligomerization domain-, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is an inflammatory complex existing in microglia. Its activation promotes the secretion of the inflammatory cytokine interleukin-1 beta/18 (IL-1 beta/18) and induces pyroptosis, a type of cell death that possesses the potential for inflammation, to rupture microglia to further release IL-1 beta. In this review we focus on the mechanisms of activation of the NLRP3 inflammasome and pyroptosis and their inflammatory effects on the development of PD. In addition, we focus on some inhibitors of NLRP3 inflammatory pathways to alleviate the progression of PD by inhibiting central inflammation and provide new therapeutic strategies for the treatment of PD.
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