Journal
INTEGRATIVE CANCER THERAPIES
Volume 18, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735419834353
Keywords
secondary primary cancers; esophageal cancer; head and neck cancer; Chinese herbal medicine; cohort study
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Funding
- National Research Institute of Chinese Medicine, Ministry of Health and Welfare [MOHW106-NRICM-C-104-000002]
- Taipei Chinese Medical Association [TPCMA2018-Research02]
- Health and welfare surcharge of tobacco products
- China Medical University Hospital Cancer Research Center of Excellence [MOHW107-TDU-B-212-114024]
- China Medical University Hospital [DMR107-164, DMR-107-192, CRS-106-001]
- Chinese Medicine Research Center, China Medical University under the Higher Education Sprout Project, Ministry of Education in Taiwan [CMRCCHM-1]
- Ministry of Health and Welfare, Taiwan [MOHW107TDU-B-212-123004]
- Academia Sinica Stroke Biosignature Project [BM10701010021]
- MOST Clinical Trial Consortium for Stroke [MOST 106-2321-B-039-005]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
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Background: Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). Objectives: The aim of this study is to evaluate whether Chinese Herbal Medicine (CHM) is correlated with reduced occurrence of second primary cancer (SPC) of head and neck (H&N) in patients with esophageal cancer (EC). Method: We identified 15,546 patients who were diagnosed with esophageal cancer between Jan 1, 2000, and Dec 31, 2010. The patients with H&N cancer before receiving CHM were excluded. After the selection and matching process, both CHM and non-CHM cohorts each contained 850 individuals. We compared the cumulative incidence of SPC of H&N with or without CHM treatment in patients with EC by the Kaplan-Meier method. NodeXL is used to run a network analysis of CHM to examine the association between herbs and formulas. Results: Compared with non-CHM users, CHM-users showed a reduced incidence rate of SPC of H&N among the patients with EC. Reduced cumulative incidence of SPC of H&N among patients with EC was noted in the CHM cohort compared to the non-CHM cohort. The most commonly used single herbs and formulas were associated with reducing SPC occurrence. Conclusion: We propose that CHM as an adjuvant therapy may prevent the occurrence of SPC of H&N in patients with EC.
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